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・ WRKJ
・ WRKK
・ WRKL
・ WRKM
・ WRKN
・ WRKO
・ WRKQ
・ WRKR
・ WRKS
・ WRKT
・ WRKU
・ WRKW
・ WRKX
・ WRKY protein domain
・ WRKY transcription factor
WRKY transcription factor family
・ WRKY-FM
・ WRKZ
・ WRL
・ WRLA
・ WRLB
・ WRLC
・ WRLC (FM)
・ WRLD
・ WRLE-LP
・ WRLF
・ WRLH
・ WRLH-DT2
・ WRLH-TV
・ WRLL


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WRKY transcription factor family : ウィキペディア英語版
WRKY transcription factor family

WRKY transcription factors are key regulators of many processes in plants. These include the responses to biotic and abiotic stresses, senescence, seed dormancy and seed germination and some developmental processes.〔Rushton PJ, Somssich IE, Ringler P, Shen QJ: WRKY transcription factors. Trends in plant science 2010, 15(5):247-258〕 Like many transcription factors, WRKY transcription factors are defined by the presence of a DNA-binding domain, in this case called the WRKY domain (WRKY protein domain). The WRKY domain was named in 1996 after the almost invariant WRKY amino acid sequence at the N-terminus and is about 60 residues in length. In addition to containing the ‘WRKY signature’ WRKY domains also possess an atypical zinc-finger structure at the C-terminus (either Cx4-5Cx22-23HxH or Cx7Cx23HxC). Most WRKY transcription factors bind to the W-box promoter element that has a consensus sequence of TTGACC/T.
==The History of WRKY Transcription Factors==
In 1994 and 1995, the first two reports of WRKY transcription factors appeared. They described newly discovered but as yet ill-defined DNA binding proteins that played potential roles in the regulation of gene expression by sucrose (SPF1) 〔Ishiguro, S. and Nakamura, K. (1994) Characterization of a cDNA encoding a novel DNA-binding protein, SPF1, that recognizes SP8 sequences in the 50 upstream regions of genes coding for sporamin and beta-amylase from sweet potato. Mol. Gen. Genet. 244, 563–571〕 or during germination (ABF1 and ABF2).〔Rushton, P.J. et al. (1995) Members of a new family of DNA-binding proteins bind to a conserved cis-element in the promoters of alpha- Amy2 genes. Plant Mol. Biol. 29, 691–702〕 A third report appeared in 1996 that identified WRKY1, WRKY2 and WRKY3 from parsley. The authors named the new transcription factor family the WRKY family (pronounced ‘worky’) after a conserved amino acid sequence at the N-terminus of the DNA-binding domain.〔Rushton, P.J., Torres, J.T., Parniske, M., Wernert, P., Hahlbrock, K. and Somssich, I.E. (1996) Interaction of elicitor-induced DNA-binding proteins with elicitor response elements in the promoters of parsley PR1 genes. EMBO J. 15, 5690–5700〕 The parsley WRKY proteins also provided the first evidence that WRKY transcription factors play roles in regulating plant responses to pathogens. Numerous papers have now shown this to be a major function of WRKY transcription factors. Since these initial publications, it has become clear that the WRKY family is among the ten largest families of transcription factors in higher plants and that these transcription factors play key roles in regulating a number of plant processes including the responses to biotic and abiotic stresses, germination, senescence, and some developmental processes.〔Eulgem, T. and Somssich, I.E. (2007) Networks of WRKY transcription factors in defense signaling. Curr. Opin. Plant Biol. 10, 366–371, Ulker, B. and Somssich, I.E. (2004) WRKY transcription factors: from DNA binding towards biological function. Curr. Opin. Plant Biol. 7, 491–498〕

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